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Hotel Exterior
Spacious lobby Holiday Inn Express and Suites San Antonio
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Holiday Inn Express & Suites San Antonio Medical-Six Flags

Your Homebase for the Best of San Antonio

Discover a seamless blend of convenience and comfort at Holiday Inn Express & Suites Medical-Six Flags, just off I-10 and only 20 minutes from the heart of San Antonio. With a location that puts you minutes from San Antonio’s top attractions, medical hubs, and corporate centers, we make every stay unforgettable.

Business travelers love our easy access to major players like USAA, Valero HQ, and the San Antonio Medical Center, paired with our 24-hour Business Center, free high-speed internet, and complimentary hot breakfast to kick-start each day.

For adventure seekers, our location brings Six Flags Fiesta Texas, SeaWorld, and the iconic Alamo within reach. Wander the River Walk’s lively scene, explore art at McNay, or unwind at the Botanical Garden. And whether you’re here for a UT San Antonio game or shopping at La Cantera Mall, you’re never far from the action.

Kids eat free
Kids eat free
Free breakfast
Free breakfast
Daily housekeeping
Daily housekeeping
Fitness center
Fitness center
On-site parking
On-site parking
Pool
Pool
Smoke-free hotel
Smoke-free hotel
Wi-Fi
Wi-Fi
Area shuttle
Area shuttle
Kids eat free
Kids eat free
Free breakfast
Free breakfast
Daily housekeeping
Daily housekeeping
Fitness center
Fitness center
On-site parking
On-site parking
Explore all amenities

Accommodations

King Bedroom near the San Antonio Medical Center

Standard Rooms

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Guest Room

Suite

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King Bedroom near the San Antonio Medical Center

Standard Rooms

Book Now
Guest Room

Suite

Book Now
Map

Reservations:

Front desk: 1-210-5619058

Email: frontdesk@hiexsamed6.com

11010 Interstate Highway 10 West San Antonio, Texas 78230 United States

Parking and transportation details

Check-in: 4:00 PM

Check-out: 11:00 AM

Minimum check-in age: 21

The highlights
Our San Antonio hotel features a stunning resort-style outdoor pool, complete with a soothing waterfall and a separate children's pool for family fun. Whether you're looking to relax or let the kids splash around this beautiful pool is the perfect spot. Open daily from 10:00 AM to 10:00 PM, it’s an ideal place to unwind and create lasting memories.

Poolside Relaxation for the Whole Family

Our San Antonio hotel features a stunning resort-style outdoor pool, complete with a soothing waterfall and a separate children's pool for family fun. Whether you're looking to relax or let the kids splash around this beautiful pool is the perfect spot. Open daily from 10:00 AM to 10:00 PM, it’s an ideal place to unwind and create lasting memories.

Nestled in the heart of San Antonio, Holiday Inn Express & Suites Medical-Six Flags is just minutes from USAA headquarters, UTSA, and the San Antonio Medical Center area. Perfectly positioned for both business and leisure, you'll enjoy easy access to top attractions, dining, and entertainment—all while staying in a prime, central location.

Central Location, Close to USAA and UTSA

Nestled in the heart of San Antonio, Holiday Inn Express & Suites Medical-Six Flags is just minutes from USAA headquarters, UTSA, and the San Antonio Medical Center area. Perfectly positioned for both business and leisure, you'll enjoy easy access to top attractions, dining, and entertainment—all while staying in a prime, central location.

Located just five miles from our hotel, Six Flags Fiesta Texas is your gateway to family fun and adventure. From heart-racing roller coasters to entertaining shows, there’s something for everyone. It’s the perfect spot for making unforgettable memories with the whole family, all just a quick drive away!

Quick Drive to Six Flags Fiesta Texas

Located just five miles from our hotel, Six Flags Fiesta Texas is your gateway to family fun and adventure. From heart-racing roller coasters to entertaining shows, there’s something for everyone. It’s the perfect spot for making unforgettable memories with the whole family, all just a quick drive away!

Host your next event in our extensive San Antonio meeting space, with room to accommodate up to 130 guests. Featuring spacious layouts, as well as a welcoming atrium reception area, Holiday Inn Express & Suites Medical-Six Flags is the perfect setting for memorable gatherings, from business meetings to special celebrations.

Versatile Space for Meetings and Gatherings

Host your next event in our extensive San Antonio meeting space, with room to accommodate up to 130 guests. Featuring spacious layouts, as well as a welcoming atrium reception area, Holiday Inn Express & Suites Medical-Six Flags is the perfect setting for memorable gatherings, from business meetings to special celebrations.

Our hotel offers a range of great amenities to enhance your stay. Take a dip in our resort-style pool, stay active in the 24-hour fitness center, and enjoy the convenience of our complimentary shuttle. With free Wi-Fi and a delicious free breakfast each morning, we’ve got everything you need for a comfortable and enjoyable visit.

Great Amenities to Make Your Stay Perfect

Our hotel offers a range of great amenities to enhance your stay. Take a dip in our resort-style pool, stay active in the 24-hour fitness center, and enjoy the convenience of our complimentary shuttle. With free Wi-Fi and a delicious free breakfast each morning, we’ve got everything you need for a comfortable and enjoyable visit.

Explore Holiday Inn Express & Suites San Antonio Medical-Six Flags

Guest Room

Sleep well, rest easy

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Discover a resort-style gem among San Antonio hotels with pools.

Elevate your experience

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Welcome to Holiday Inn San Antonio Medical-Six Flags!

See it to believe it

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Guest Room

Sleep well, rest easy

View rooms
Discover a resort-style gem among San Antonio hotels with pools.

Elevate your experience

View amenities
Welcome to Holiday Inn San Antonio Medical-Six Flags!

See it to believe it

View photos

Hotel packages available

Prices shown reflect an average per night stay from

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FAQs for Holiday Inn Express & Suites San Antonio Medical-Six Flags

Yes, Holiday Inn Express & Suites San Antonio Medical-Six Flags has an outdoor pool.
Complimentary parking is available at Holiday Inn Express & Suites San Antonio Medical-Six Flags for hotel guests.
Always check the hotel's cancellation policy before booking a rate. Room cancellation is subject to rate booked at time of reservation and cancellation policy varies by rate.
No, there is no on site restaurant at Holiday Inn Express & Suites San Antonio Medical-Six Flags.
Breakfast is free with your stay at the Holiday Inn Express & Suites San Antonio Medical-Six Flags.
Breakfast at Holiday Inn Express & Suites San Antonio Medical-Six Flags is available from 6:30 AM to 9:30 AM.
Yes, Holiday Inn Express & Suites San Antonio Medical-Six Flags offers a complimentary local area shuttle. Check our Transportation page for more details.
Check-in at Holiday Inn Express & Suites San Antonio Medical-Six Flags is from 4:00 PM, and check-out time is 11:00 AM. Contact the hotel directly for options available for early check-in or late check-out.
Yes, the Holiday Inn Express & Suites San Antonio Medical-Six Flags offers free WiFi!
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